产品货号：
Z21624
中文名称：
Nicastrin/NCSTN抗体
英文名称：
Anti-Nicastrin/NCSTN Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Nicastrin/NCSTN Antibody |
| 指标别名 | APH2;KIAA0253;NCSTN;nicastrin |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | NCSTN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Nicastrin antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Nicastrin.The immunogen is located within amino acids 630 - 680 of Nicastrin. |
| 计算分子量 | 78kDa |
| 成分 | Nicastrin Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Nicastrin Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Nicastrin,in addition to presenilin,PEN2,and APH-1 forms the gamma-secretase protein complex,a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer.This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease.Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families,gamma-secretase will cleave the amyloid precursor protein (APP),but within the intramembrane region of APP,resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site).It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.Nicastrin is also thought to be involved in cell proliferation and signaling,especially in regards to activation of Notch receptors as loss of Nicastrin expression results in mouse embryonic lethality. |
| Uniprot ID | Q92542 |
| 基因名全称 | Nicastrin |
| 蛋白名全称 | Nicastrin |
| 推荐稀释比 | Nicastrin antibody can be used for detection of Nicastrin by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
相关搜索：Nicastrin/NCSTN抗体，Nicastrin抗体，NCSTN多抗，Anti-Nicastrin/NCSTN Antibody